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参考文献: A4GNT

Desamero MJ, Kakuta S, Tang Y, Chambers JK, Uchida K, Estacio MA, Cervancia C, Kominami Y, Ushio H, Nakayama J, Nakayama H, Kyuwa S. Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma. Sci Rep. 2019 Dec 23;9(1):19635. doi: 10.1038/s41598-019-55465-4. PubMed
Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, Nakayama J. Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda. J Histochem Cytochem. 2019 Oct;67(10):759-770. doi
Desamero MJ, Kakuta S, Chambers JK, Uchida K, Hachimura S, Takamoto M, Nakayama J, Nakayama H, Kyuwa S. Orally administered brown seaweed-derived β-glucan effectively restrained development of gastric dysplasia in A4gnt KO mice that spontaneously develop gastric adenocarcinoma. Int Immunopharmacol. 2018 Jul;60:211-220. doi
Yamanoi K, Nakayama J. Reduced αGlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer. Histochem Cell Biol. 2018 Jun;149(6):569-575. doi: 10.1007/s00418-018-1667-8. Epub 2018 Apr 16. Review. PubMed
Sinha J, Cao Z, Dai J, Tang H, Partyka K, Hostetter G, Simeone DM, Feng Z, Allen PJ, Brand RE, Haab BB. A Gastric Glycoform of MUC5AC Is a Biomarker of Mucinous Cysts of the Pancreas. PLoS One. 2016 Dec 19;11(12):e0167070. doi: 10.1371/journal.pone.0167070. eCollection 2016. PubMed
Shiratsu K, Higuchi K, Nakayama J. Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach. Cancer Sci. 2014 Jan;105(1):126-33. doi
Karasawa F, Shiota A, Goso Y, Kobayashi M, Sato Y, Masumoto J, Fujiwara M, Yokosawa S, Muraki T, Miyagawa S, Ueda M, Fukuda MN, Fukuda M, Ishihara K, Nakayama J. Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest. 2012 Mar;122(3):923-34. doi
Rinaldi M, Dreesen L, Hoorens PR, Li RW, Claerebout E, Goddeeris B, Vercruysse J, Van Den Broek W, Geldhof P. Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum. Vet Res. 2011 May 11;42:61. doi
Zheng Z, Jia Y, Hou L, Persson C, Yeager M, Lissowska J, Chanock SJ, Blaser M, Chow WH, Ye W. Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk. Helicobacter. 2009 Oct;14(5):120-5. doi: 10.1111/j.1523-5378.2009.00708.x. PubMed


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